Each of these conditions can eventually lead to substance abuse, however if an individual is physiologically dependent there is evidence of tolerance or withdrawal. These individuals can often be helped with other life-sustaining medications to help them in the gradual process of completely eliminating the addiction. Individuals without physiological dependence show no signs of ever having attempted to kick their addiction, either because the pain experienced without the drug is excessive, or because they simply feel too good to be high. The DSM-IV has identified several markers for drugs