Topic > Analysis of two articles: “Elimination of Nescent Glial Cells” and “Zombie Cells Found in Mouse Brains Before Cognitive Loss”

The psychological news article I chose is titled Zombie Cells Found in Mouse Brains mice before cognitive loss loss. The author of this article is Sara Tiner of the Mayo Clinic. This article can be found on the Science Daily website, which can be found specifically at https://www.sciencedaily.com/releases/2018/09/180919133024.htm (Tiner, 2018). Say no to plagiarism. Get a tailor-made essay on "Why Violent Video Games Shouldn't Be Banned"? Get an original essayThe news source article discussed research into senescent cells. Senescent cells are unable to perform normal tasks in the brain than any other cells, but they are still alive like the others. These cells are also identified as “zombie” cells. There are two types of senescent cells: microglia and astrocytes. Zombie cells are linked to numerous cognitive diseases that develop over time due to premature aging, such as atherosclerosis, osteoarthritis and neurodegenerative diseases – specifically Alzheimer's and Parkinson's, for example (Tiner, 2018). The study was conducted on mice as their main test subjects. After eliminating senescent cells from elderly mice diagnosed with cognitive disorders, they found that this helped extend a healthier lifespan. The researchers manipulated cognitive impairments by manipulating tau protein aggressions by replicating sticky spider web neurons with specific genetic modifications that were introduced into mice. After the tau proteins were successfully inserted inside the mice, the senescent cells were completely removed. Once the senescent cells were removed, the mice were able to form memories and did not have any type of inflammation in the brain although the tau proteins were inside them (Tiner, 2018). The scientific article in which the study was originally discussed is titled Clearance of Senescent Glial Cells Prevents Tau-Dependent Pathology and Cognitive Decline. The several researchers who conducted the study are Tyler J. Bussian, Asef Aziz, Charlton F. Meyer, Barbara L. Swenson, Jan M. van Deursen, and Darren J. Baker. This article can be found in the Nature International Journal of Science (Bussain, 2018). Cell senescence is caused by an irreversible implication of the cell cycle, which is linked to a phenotype induced by intracellular and extracellular factors (Bussain, 2018). Scientists have found no reason for the use of these specific cells in the brain. The cells inhibit the p16 protein, which has been linked to diseases such as atherosclerosis, osteoarthritis, deterioration of other brain tissues, and neurodegenerative diseases (Bussain, 2018). The study used a mouse model with tau-dependent neurogenerative diseases, in which tau neurofibrillation preserved normal cognitive function in mice. The mice were female mice aged between three and six months while the male mice were ten months old (Bussian, 2018). Tau neurodegenerative diseases accumulate the two senescent cells which are microglia and astrocytes. After eliminating tau neurofibrillation from the brain, the mice retained normal cognitive function. Senescent cells were eliminated using a transgenic INK-ATTAC resulting in soluble and insoluble neurofibrillary deposition. Senescent cells play a role in tau-mediated diseases, and removing these specific neurons can help treat pathologies (Bussain, 2018). Comparing the two articles, both sources differ greatly in terms of language. There are no strategies.